Key facts about the Patris Health Ointment No. 4
Patris Health Ointment No. 4 is an excellent product that absorbs quickly and leaves your skin hydrated but not oily. It helps to revitalize your skin. This ointment is perfect for those who want to maintain healthy, beautiful and moisturized skin.
- Functional ingredients: Calcium pantothenate (Calcium salt of pantothenic acid – Vitamin B5).
- Target conditions: Dry and cracked skin, damaged skin, scars, dull and tired skin.
- Recommended use: Apply a sufficient amount of ointment to the skin at the affected area and massage until the skin absorbs the ointment. Regular use increases efficiency.
- Net volume: 84 g
- Paraben-free, Silicon-free, Not Tested on Animals
- Trade name: Patris Health Ointment No. 4
About the Calcium pantothenate (Calcium salt of Vitamin B5)
Calcium pantothenate is a name for calcium salt of pantothenic acid (Vitamin B5). It is a water-soluble vitamin that is part of the B-complex vitamins.
It is present in food sources such as meats, poultry, fish, nuts, seeds, and legumes. The body needs pantothenic acid to synthesize coenzyme A (CoA), which is vital in the metabolism of carbohydrates, fats, and proteins.1
Pantothenic acid deficiency is rare but can cause symptoms such as fatigue, muscle weakness, irritability, and digestive disturbances.
Effects of Calcium pantothenate on the skin
Calcium pantothenate has several uses in skincare products. It acts as an emollient, meaning it can help to soften and smooth the skin.
Additionally, this calcium salt of Vitamin B5 has antioxidant properties and can help to protect the skin from damage caused by free radicals. It also helps to reduce mild inflammation and redness of the skin.
What science says about the benefits of Calcium pantothenate for the skin?
The topical application of pantothenate is widely used in clinical practice for wound healing due to the stimulation of dermal fibroblast proliferation by pantothenate and panthenol.2 Due to its central role in the formation of granulation tissue, dermal fibroblast migration and proliferation are essential steps in wound healing.3
Moreover, skin fibroblasts cultured with panthenol demonstrated enhanced suppression of free radical formation.4
Proliferation is defined as the process by which a cell multiplies rapidly.
Fibroblasts are cells that contribute to the formation of connective tissue, a fibrous material that supports and connects other tissues and organs of the body.
It has been shown that calcium pantothenate accelerates wound healing by increasing the number of migrating cells, their distance, and hence their speed. Additionally, cell division is increased, and protein synthesis is changed.5
Studies have shown that pantothenic acid (vitamin B5) and panthenol (alcohol derivative of pantothenic acid) moisturize the skin well.6
List of references:
- National Cancer Institute. https://www.cancer.gov/
- Wiederholt T, Heise R, Skazik C, Marquardt Y, Joussen S, Erdmann K, Schröder H, Merk HF, Baron JM. Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8. PMID: 19397697.
- Cen R, Wang L, He Y, Yue C, Tan Y, Li L, Lei X. Dermal Fibroblast Migration and Proliferation Upon Wounding or Lipopolysaccharide Exposure is Mediated by Stathmin. Front Pharmacol. 2022 Jan 28;12:781282. doi: 10.3389/fphar.2021.781282. PMID: 35153746; PMCID: PMC8831846.
- Wiederholt T, Heise R, Skazik C, Marquardt Y, Joussen S, Erdmann K, Schröder H, Merk HF, Baron JM. Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8. PMID: 19397697.
- Weimann BI, Hermann D. Studies on wound healing: effects of calcium D-pantothenate on the migration, proliferation and protein synthesis of human dermal fibroblasts in culture. Int J Vitam Nutr Res. 1999 Mar;69(2):113-9. doi: 10.1024/0300-9831.69.2.113. PMID: 10218148.
- Daisaku Kobayashi, Miho Kusama, Masaaki Onda, Norimichi Nakahata, The Effect of Pantothenic Acid Deficiency on Keratinocyte Proliferation and the Synthesis of Keratinocyte Growth Factor and Collagen in Fibroblasts, Journal of Pharmacological Sciences, Volume 115, Issue 2, 2011, Pages 230-234, ISSN 1347-8613, https://doi.org/10.1254/jphs.10224SC.
